Multivitamin use and telomere length in women
Am J Clin Nutr 2009;89:1857–63. Qun Xu, Christine G Parks, Lisa A DeRoo, Richard M Cawthon, Dale P Sandler, and Honglei Chen
Background: Telomere length may be a marker of biological aging.
Multivitamin supplements represent a major source of micronutrients,
which may affect telomere length by modulating oxidative
stress and chronic inflammation.
Objective: The objective was to examine whether multivitamin use
is associated with longer telomeres in women.
Design: We performed a cross-sectional analysis of data from 586
early participants (age 35–74 y) in the Sister Study. Multivitamin
use and nutrient intakes were assessed with a 146-item food-frequency
questionnaire, and relative telomere length of leukocyte DNA was
measured by quantitative polymerase chain reaction.
Results: After age and other potential confounders were adjusted
for, multivitamin use was associated with longer telomeres. Compared
the relative telomere length of leukocyte DNA
was on average 5.1% longer among daily multivitamin users.
In the analysis of micronutrients, higher intakes of
vitamins C and E from foods were each associated with longer
telomeres, even after adjustment for multivitamin use. Furthermore,
intakes of both nutrients were associated with telomere length
among women who did not take multivitamins.
Conclusion: This study provides the first epidemiologic evidence
that multivitamin use is associated with longer telomere length